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KMID : 0605619990060020149
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Journal of Korean Society of Biological Psychiatry
1999 Volume.6 No. 2 p.149 ~ p.152
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Animal Models of Alzheimer's Dementia
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1/2우성일/12Sung Il Woo
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Abstract
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Transgenic mice models of Alzheimer's disease were produced by overexpressing
APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors
that induced neuronal expression.
The neuropathologies, electrophysiological changes and behavioral changes that were
demonstrated in these transgenic mice model were amyloid changes, gliotic changes.
A-beta increases, deficit in LTP(ling-term potentiation) and behavioral changes. Some or
all of the above changes were found in each transgenic mice model.
These models generally showed amyloid neuropathology but they usually lacked the
neurofibrillary tangles. So, they can be regarded as partial models of Alzheimer's
disease. The development of them is undoubtedly the great progress toward future
research.
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KEYWORD
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